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Dose escalation without clear non-response is guesswork, not pharmacology

It helps to regulate human body functions, such as cell multiplication, blood formation, and protein synthesis

Hence, the PIE of tirzepatide is antagonized by exendin and is therefore in part mediated by GLP-1R

Upon entry into the parenchyma, these cells initiate a secondary immune response, releasing inflammatory mediators such as cytokines, chemokines, proteases, and toxic substances, aggravating myelin and axonal damage [263]