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Regarding safety, L-glutathione is generally very well tolerated, as it is a naturally occurring compound in the body

While research suggests it is safe and well-tolerated in short-term studies when administered in carefully controlled pulses, its unapproved status means: Long-Term Effects are Unknown: The full impact of chronic use on cardiovascular health, glucose regulation, or promotion of latent malignancies is not fully established via large-scale human trials

Am J Reprod Immunol (2019) 82(3):e13151

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These antibodies can potentially neutralize drug activity or alter pharmacokinetic properties