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The safety profile of DUPIXENT TCS in subjects followed through Week 52 was similar to the safety profile observed through Week 16 in AD-1652

Given that GLP-1 936 amide is the major circulating form of GLP-1 post-prandially and is a low affinity weak partial agonist or antagonist at the GLP-1R, we investigated interaction between this metabolite and compound 2 in a cell line with recombinant expression of the human GLP-1R and the rat insulinoma cell line, INS-1E, with native expression of the GLP-1R