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Retatrutide at 12 mg weekly currently produces the largest weight loss of any published Phase 3 GLP-1-class compound, exceeding tirzepatide (22.5% in SURMOUNT-1) and semaglutide (14.9% in STEP-1) at comparable timepoints
Trifluoroacetic acid (TFA): Once a peptide chain is complete, this notoriously aggressive acid cleaves it from the resin bed
The WHO guidelines call for urgent action on manufacturing, affordability, and system readiness, recommending strategies such as pooled procurement, tiered pricing, and voluntary licensing to expand global access [51]
