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How Direct Meds compares to brand-name pricing For context, here is what brand-name semaglutide costs without insurance: Ozempic: approximately $997 per month Wegovy: approximately $1,349 per month Rybelsus (oral): approximately $936 per month Direct Meds compounded semaglutide at $249 to $297 per month represents roughly a 70 to 75 percent cost reduction compared to brand-name options