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It exists naturally in human plasma, saliva, and urine with plasma concentrations averaging ~200 ng/mL at age 20 but declining to ~80 ng/mL by age 60

Despite increasing attention, current evidence remains limited to in vitro and animal research, with important gaps in long term data and standardized methodologies

Monitor for hypoglycaemia when used with other glucose-lowering medications, particularly if experiencing unexplained sweating, tremor, confusion, or palpitations

As for dosages, the studies using micronized PEA, the range was from 10 to 15 mg/kg/day, and the range for ultra-micronized was 24 mg/kg (for osteoarthritis)