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Gastrointestinal symptoms - Diarrhea, constipation, abdominal discomfort, vomiting Reduced appetite - While this contributes to weight loss, some people find it makes eating adequate nutrition challenging Fatigue - Some individuals report feeling more tired, particularly in the first few weeks Injection site reactions - Redness, itching, or mild discomfort at injection sites (for injectable formulations) Most side effects are dose-dependent and tend to improve as the body adjusts
doi: 10.1056/NEJMoa2404881 [DOI] [PMC free article] [PubMed] [Google Scholar] 204.Fadini GP
63 Furthermore, potential side effects like nausea or vomiting can lead to fluid loss, and dehydration can worsen common issues like constipation, fatigue, and headaches
With tirzepatide, decreased exposure to oral contraceptives may occur during initiation and dose escalation
