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Stress-exposed C- Glud1 +/ mice show deficits in spatial acquisition and reversal in a water T-maze task, unlike their stress-nave C- Glud1 +/ and stress-exposed C-Cre+ littermates

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The aromatase gene is directly regulated by CREB (107), and this enzyme converts androgens (e.g., testosterone) to estrogens, while StAR mediates the transport of cholesterol substrate to the mitochondria for synthesis of testosterone, E2 and P4 in steroidogenic cells (Figure 2)

Tirzepatide commonly causes nausea, vomiting, diarrhea, and decreased appetite, particularly during dose escalation