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Why Nausea Occurs with Retatrutide Dosing Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors overwhelming the digestive system Retatrutide activates GLP-1, GIP, and glucagon receptors simultaneously , leading to strong effects on: Appetite suppression Gastric emptying Central satiety signaling Energy expenditure Nausea most often results from rapid or intense GLP-1 receptor activation , especially when the body has not yet adapted to the peptide

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Further information is available on the NHS Diabetic Ketoacidosis (DKA) page