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Key modulations are dependent on tumor cell metabolism, cell interactions in TME, tumor heterogeneity, and whole-body metabolism homeostasis (Elia and Haigis, 2021)

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6.4 Predictive testing in vivo 6.4.1 Testing for skin allergy 6.4.1.1 Testing in guinea-pigs The guinea-pig was for many years the animal of choice for experimental studies of contact sensitization, and several test methods were developed in this species

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ROS quantification was performed on a Spark Multimode Microplate Reader (Tecan Life Sciences, Mannedorf, Switzerland) at an Ex/Em of 485/535 hourly for 8 h