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While some of these effects can be beneficial in specific contexts, they create complexity, side effects, and potential contraindications that limit the applicability of growth hormone therapy for individuals seeking primarily fat loss

FDA nonclinical toxicology review (2023-2024) flagged DNA damage in pituitary cells and injection-site necrosis in animal studies, plus immunogenicity and impurity risks from compounded material, alongside GH/IGF-1-axis effects such as fluid retention, joint discomfort, flushing, and headache reported by users

Since its first description in the peer-reviewed literature by Neelakantan et al

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Studies have examined the implications of altered methylation patterns for gene expression and cellular function