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Six to eight month old C57BL/6 mice were injected with 400,000 B 16-F10 cells in 200 PBS by tail vein injection and subsequently received daily intraperitoneal injections of either D-Nle-X-Cys-NH-(CH 2 ) 5 -CONH 2 (10 Mg/kg and 100pg/kg) or a PBS vehicle control

Long-term remodeling (weeks 2-8+) shows improved collagen maturation and tissue strengthening

doi: 10.1016/j.amjms.2016.01.011 Lau LH, Lew J, Borschmann K, Thijs V, Ekinci EI