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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23
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Based on the data from both normal and dopamine-depleted animals, we hoped to confirm that the disruption of D2R-DAT stimulates locomotor behavior by directly enhancing dopaminergic neurotransmission
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