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In fact, serotonin manages glutamate pathways differentially across the brain: In the CNS, 5-HT exerts a very complex modulatory control over glutamate- and GABA-mediated transmission, involving many subtypes of 5-HT receptors and a large variety of effects

Tumor necrosis factor- (NF-) activates the NF-B, which promotes the adhesion to the surface of endothelial and vascular smooth muscle cells of molecules causing an inflammatory state of adipose tissue, dysfunction of the endothelium, and finally, atherogenesis [61]