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Thus, this evidence supports the conclusion that, in addition to rigorous lifestyle interventions, pharmacological gains must be evaluated via stratification based on specific populations and target endpoints

"There's a plausible biologic hypothesis to say that these drugs, in addition to weight loss, could have independent effects on inflammation that could be important for both tumor genesis and cancer growth," McDonald said

The risk of an UTI was found to be slightly higher in group receiving sequential combination therapy (relative risk [RR] 0.96, 95% confidence interval [CI] 0.521.78) than in simultaneous combination group (RR 0.67, 95% CI 0.281.60) [57]

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Unlike GLP-1 options, results depend heavily on lifestyle consistency