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It is worth noting that HA exhibits favorable lubricating properties, particularly when cross-linked, as it forms a liquid matrix on the ocular surface

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These include: Ergotamine or ergot derivatives like dihydroergotamine (Migranal, Ergomar) Other triptans such as sumatriptan (Imitrex), rizatriptan (Maxalt), zolmitriptan, naratriptan, frovatriptan, or almotriptan within 24 hours Strong CYP3A4 inhibitors such as ketoconazole (Sporanox), itraconazole, clarithromycin, ritonavir, nelfinavir (Viracept), and nefazodone These drug interactions can increase eletriptan levels in the body and raise the risk of serious side effects, including coronary artery vasospasm and arrhythmias

Third, the two medications reach peak blood levels at different rates, which influences the timing and intensity of symptoms

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