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Frontiers in Microbiology, 12 , 639948

As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]

These were led by Ivy who was the president of the American Physiological Society from 1939 to 1941

doi:10.3390/nu11112611 Shi Q, Nong K, Vandvik PO, et al

Brown, S