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Human trials showed that in people with high-risk features, treatment with minocycline reduced in 6 months the risk of conversion to MS, decreased lesion volume, and showed the absence of new enhancing lesions, but this effect did not last beyond 24 months of study (Preiningerova et al., 2022)

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Long-term studieslike STEP and SELECT trialsshow 1015% body weight loss sustained over multiple months to years, with substantial abdominal fat reduction