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However, which signaling pathway produces the unwanted side effects (such as respiratory suppression and constipation) is currently controversial: one view is that it is caused by -arrestin signal transduction, and the other view suggests that the respiratory depression by opioids is caused due to G protein-gated inwardly rectifying potassium (GIRK) channel signaling

Decoding Glutathione This popular ingredient of many health and beauty products is a powerful antioxidant produced naturally by the liver and found in many dietary sources

Qureshi-Baig, K., Ullmann, P., Haan, S

doi: 10.3390/nu14081549

The first reason is related to slowed gastric emptying