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Safety and Tolerability Considerations Semaglutide is generally well-tolerated when doses are increased slowly, but gastrointestinal side effectsnausea, vomiting, constipationare common during titration

Giralt M, Cereijo R, Villarroya F

Pharmacol Biochem Behav 163:5765 Tomaz V, Chaves Filho A, Cordeiro R, Juc P, Soares M, Barroso P, Cristino L, Jiang W, Teixeira A, de Lucena D, Macedo D (2020) Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression

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Figure 1 Although there are still unclear data on how much improvement in hyperglycemia in diabetic patients is needed to affect T and the entire HPG axis, the identification of effective and early treatments may prevent irreversible organ-damage