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378 Astrocytic overload with iron however significantly reduces glutamate clearance by down-regulation expression of EAAT1 glutamate transporters 379 and impairs operation of the glymphatic system

However, high-dose L-carnitine therapy provides a massive amount of fuel for gut bacteria, causing them to produce more TMA than the livers FMO3 enzymes can process at one time [12] [13]

Through histone modification, curcumin downregulates histone acetyltransferases (p300/CBP) and histone deacetylases (HDAC1, HDAC3), restoring normal chromatin architecture and transcriptional activity of growth-regulating genes (Reuter et al., 2011)

1,2 Inflammatory bowel disease (IBD) is a group of chronic incurable gastrointestinal inflammatory disorders with undetermined etiology