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Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: purification and properties of the NAD(P)+-dependent enzyme

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Moreover, we observed a pattern of gene expression consistent with the response to an iron overload, such as the upregulation of HMOX1 (encoding heme oxygenase 1) 69 , SLC40A1 (encoding ferroportin), FTH1 and FTL (encoding ferritin heavy and light chains, respectively) 70 , and metallothioneins 71 (Fig

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Ferroptosis in these cells disrupts immune homeostasis and contributes to inflammation and tissue injury ( Figure 5 )