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Tirzepatide (which activates both GLP-1 and GIP receptors) has demonstrated superior weight loss and metabolic outcomes compared to semaglutide alone in clinical trials, with weight reductions exceeding 20% in some cohorts

6 Moreover, GIPR signaling blocks emesis and attenuates other negative side effects of GLP-1 receptor (GLP-1R) activation

Despite the common morphological hallmarks and shared triggers, it has become clear that the signaling pathways might differ