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For readers comparing GLP-1 options and side-effect profiles, our tirzepatide side effects guide explains what to expect and how nausea can differ across treatment plans

While typically manageable, these effects can affect how well patients tolerate the drugs over time

As additional data and competing therapies emerge, treatment algorithms will continue to evolve, but Wegovys current evidence base positions it as a central, though not universal, tool in contemporary cardiometabolic and liverdisease management

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Metformin reduced cardiovascular events in new-onset diabetes patients with obesity in the UK Prospective Diabetes Study (UKPDS 34) [25], but not in DPP/DPPOS [26], and some meta-analyses have shown controversial results [27, 28]