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Presentation : Bi-12 IV/IM Injection 500 mcg/ml Box, 5 ampoules @ 1 ml On medical prescription only Store below 30C, protect from light

Unlike topical skincare, which works on the surface, oral supplementation interacts with internal biological systems

Clinical studies indicate positive effects on DPN symptoms and nerve function

Abbreviations 4E-BP1 Eukaryotic translation initiation factor 4E-binding protein-1 6W Six-minute walk test AEs Adverse events BMI Body mass index Comp Composite endpoint DXA Dual-energy X-ray absorptiometry ITT Intent-to-treat LS Lower strength MM Muscle mass mTOR Mammalian target of rapamycin MuRF1 Muscle RING-finger protein-1 NNHPD Natural and non-prescription health products directorate NSAID Non-steroidal anti-inflammatory drug PP Per-protocol QoL Quality of life S6K p70-S6 kinase UPS Ubiquitinproteasome system US Upper strength Additional file Contributor Information Malkanthi Evans, Email: [email protected]

The hemoglobinemia and hemoglobinuria are present