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These findings establish a consensus-driven and transferable computational framework for chemotype-diverse agonist discovery at conformationally flexible GPCR targets, and revealed a pentapeptide with GLP-1-like efficacy as a promising lead for next-generation small peptide therapeutics

It is generally recommended to stop GLP-1 receptor agonist medications such as Ozempic, Mounjaro or Wegovy before conception and allowing for a washout period of approximately 23 months

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[63] This was followed by the development of semaglutide by a team of researchers at Novo Nordisk, including Jesper Lau, Thomas Kruse, and Paw Bloch

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