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Glucoregulatory Hormones and GLP-1/GIP Receptor Agonists Introduction The quest for more physiologic approaches to augment insulin treatment prompted investigation of glucoregulatory hormones

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GLP-1RAs ameliorate ROS-induced or hyperglycemia-induced apoptosis through modulating IL-6 production and ER stress-induced by hyperhomocysteinemia, via stromal cell-derived factor (SDF)-1/C-X-C motif receptor 7 (CXCR7) -AMPK/p38-MAPK axis [113-115]