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But in practice the scientists had to test out a number of different linker molecules, and chemically modify the GLP-1 structure slightly, in order to get the new drug to work

46 In patients with T2DM, the Tirzepatide versus Semaglutide once weekly in patients with T2DM (SURPASS-2) trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks

The study of Sai et al

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Since some adverse effects such as serious infections and skin cancers were reported, additional evaluation of the safety profile of this drug is needed (Gordon 2012