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Schroeder EB, Xu S, Goodrich GK, Nichols GA, OConnor PJ, Steiner JF

Arch Biochem Biophysiol 89:303308 De Benedetto F, Pastorelli R, Ferrario M et al (2018) Supplementation with Qter and creatine improves functional performance in COPD patients on long term oxygen therapy

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Patients on chronic therapy should maintain regular follow-up with their healthcare provider, including monitoring for adverse effects, assessment of treatment efficacy, and evaluation of ongoing appropriateness of therapy

At the same time, a slower, gradual increase in dose helps reduce gastrointestinal side effects and lowers dropout rates