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I was delighted to see the results of the awaited FLOW trial in the NEJM

Meersseman P, Boonen E, Peeters B, Vander Perre S, Wouters PJ, Langouche L, et al

Glucuronidation is commonly present at low capacity in the fetus, newborns, and young infants, such that exposure to acetaminophen at these times leads to greater metabolism by other pathways

The symptom typically plateaued and began improving as participants entered weeks 4 through 8, suggesting that the body's adjustment mechanisms were active during this window