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reported that Rac1 and Rac2 are essential for the structural integrity of the murine RBC cytoskeleton and are implicated in sickle cell formation [178]

At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

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