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This single small molecule affects more than 31% of human genes, upregulating repair pathways while simultaneously suppressing inflammatory and potentially harmful gene expressions

S.BrietzkeE.SubramanieapillaiM.et al (2020)

[7] [8] Similarly, individuals scheduled for surgery should inform their surgical and anaesthetic team about all supplements they take

Fumaric acid accumulation also inhibits the activity of adenylosuccinate lyase (ADSL) in the purine de novo synthesis pathway, resulting in an increase in succinylaminoimidazolecarboxamide ribose (SAICAR) and adenosine succinate, which can cause damage to the central nervous system [84]

The research paper, Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study , was published in the Journal of Neurology, Neurosurgery & Psychiatry