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The most common side effects of GIP/GLP1 receptor agonists include nausea, vomiting, constipation, dyspepsia, and diarrhea, as shown in the SURMOUNT 3 trial

For both studies, the treatment differences were back-transformed to present the ratios of geometric least squares means (GLSM) and the corresponding 90% CIs for the fed versus fasted arms

doi: 10.3389/fncel.2015.00003

The genes affected by semaglutide included markers of inflammation and plaque stability that are associated with leukocyte recruitment [e.g., interleukin-1 (IL-1) receptor antagonist, IL-6, monocyte chemoattractant protein (CCL2), OPN], leukocyte adhesion [selectin E, vascular cell adhesion molecule-1 (VCAM1)], leukocyte extravasation and plaque stability (e.g., MMP3, MMP13, CCL2), and plaque rupture and hemorrhage (CD163)

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