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Am J Clin Nutr

NNMT inhibition increases availability of NAD+ and influences metabolic processes, allowing the body to burn more calories while suppressing additional glycogen and fat deposits

Reducing the dose or switching forms may help

This means that there is less ability in the cells of people with Down syndrome to perform the chemical reaction (methylation)

How 5-Amino-1MQ Started as a Metabolic Molecule Before Evolving in Longevity Originally, longevity researchers were most interested in applying their knowledge of NAD+ and 5-Amino-1MQs ability to inhibit NNMT and exploring its potential benefits for fat loss, metabolic function, and energy support