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They investigated the relationship between intestinal flora imbalance and severe MASLD lesions (MASH and fibrosis) and showed that an increase in the number of Ruminococcus was positively associated with an aggravation of the degree of fibrosis (76)

Clinical studies demonstrate Abdominal Relief: 63% of participants in the test group reported complete resolution of discomfort in 5 days vs 13% in the placebo group Constipation Resolution: improvement for 98.6% of study participants IBS Symptom Reduction: Significant improvements in bloating/cramping (78%), diarrhea/constipation (64%) & abdominal pain (80%) Regulatory Confidence After a rigorous scientific review of its safety and efficacy, SEBiotic was granted a GRAS (Generally Recognized as Safe) No Objections Letter from the FDA

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Moreover, the DPP-4-generated metabolites of GLP-1 (Figure 1), lacking the His-Ala dipeptide, have 100-fold less affinity towards GLP-1R