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The evidence supporting this model includes the tissue-specificity of epithalamin's original effects, the concentration-dependence of Epithalon's chromatin remodeling activity, and the correspondence between Epithalon's sequence and sequences identifiable within larger pineal-expressed proteins

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GHRH and its analogs and GH secretagogues fall within the World Anti-Doping Agencys prohibited hormone-and-metabolic-modulator category, and GHRH-receptor agonists such as tesamorelin and CJC-1295 are treated as prohibited