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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26

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A non-significant reduction in coronary plaque volume, decrease in liquid plaque volume, and a decrease in non-HDL cholesterol was observed in the sitagliptin group [81]

Food preferences often shift naturally toward lighter, healthier options

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