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Compounds that selectively kill senescent cells (senolytics) can treat different age-related pathologies 12

Understanding the molecular and cellular mechanisms underlying the loss or gain of disorder-related detrimental effects mediated by astrocytes in different contexts has the potential to identify new treatment strategies for a wide variety of CNS disorders

OTUD1 activates caspase-independent and caspase-dependent apoptosis by promoting AIF nuclear translocation and MCL1 degradation

& Lucey, M