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The expanded CD28(null)Tang subset, associated with aging, intensifies endothelial inflammation via inflammatory factor release, leading to atherosclerosis and linked to SLE disease activity (72, 73)

Increased Lipid Peroxidation: By promoting oxidative stress, NSAIDs may accelerate lipid peroxidation, a process in which free radicals attack cell membranes

Without such institutional reforms, the successful implementation of SUMP initiatives will remain elusive, and the potential of these plans will be limited by inefficiencies and conflicting priorities across sectors