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Despite lowering testosterone levels, short-term GLP-1 treatments dont significantly improve hirsutism scores after 6 months, even when weight and testosterone improved

Comparative risk of incident malignancies in rheumatoid arthritis patients treated with Janus kinase inhibitors or bDMARDs: observational data from the German RABBIT register

the interaction with growth hormone secretagogues, which may raise glucose, is unpredictable Cardiovascular effects increased heart rate has been observed with GLP-1-based therapies

GLPs also appear to have an effect on the immune system and inflammation