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Ferroptosis resistance in tumor cells In addition to System X c /GSH/GPX4 axis, an antioxidant system that protect tumor cells from ferroptosis, a number of new mechanisms of ferroptosis resistance have been found in vivo and in vitro studies of drug-resistant solid tumors mentioned above, which are associated with a variety of metabolic enzymes

BMSC-Exos limit oxidative stress, inhibit cell death and ACSL4 expression, and prevent OA progression [175] (Table 1)

Because of this, it has gained popularity as a possible alternative for individuals seeking fat reduction strategies with fewer systemic effects