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While the body makes CoQ10 naturally, levels decrease with age, stress, and certain medicationsespecially statins(cholesterol-lowering drugs)

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Factors responsible for the liver's contribution to drug metabolism include that it is a large organ, that it is the first organ perfused by chemicals absorbed in the gut, and that there are very high concentrations of most drug-metabolizing enzyme systems relative to other organs

Vitiligo with progressive repigmentation during secukinumab treatment in a patient with Psoriatic Arthritis: a case report