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In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200202)

Lim, Y., Leslie, S

many patients begin with a short series of injections spaced over weeks, then shift to a maintenance schedule that holds the gains

It binds the same pituitary receptor that the bodys own GHRH targets, telling the pituitary gland to release growth hormone in the same way it would naturally

You cant overdose on b12, your body will store any excess in the liver or excrete into your urine