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Pharmacokinetics and tolerability of the ADCs in SD rats

In elderly and debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2 mg once or twice daily, initially, to be increased gradually as needed and tolerated)

4.2 Protein deglycase-1 (DJ-1) A mutation in the 189-amino acid protein DJ-1 was reported to be related to a rare family autosomal recessive PD (Farah et al., 2018)