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Because FOXO4-DRIs mechanism depends on disrupting the FOXO4p53 interaction, and because this interaction is only operative in cells with elevated FOXO4 expression, the compound preferentially targets the senescent cell population leaving FOXO4-low non-senescent cells largely unaffected

However, it can be found in foods like fish, eggs, meat and dairy products

Despite these positive results, the transition from animal to human model did not give the same encouraging outcomes, since most of clinical trials failed (71, 72)

Author contributions NM: Conceptualization, Data curation, Investigation, Project administration, Resources, Writing review & editing

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