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Adding oral B12, sublingual B12, or additional B12 injections poses no risk

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One of the major unresolved issues is the temporal and mechanistic hierarchy of organelle dysfunction in AP, particularly the relative sequence linking Ca 2+ overload, mitochondrial depolarization, bioenergetic failure, oxidative stress, defective mitophagy, inflammasome activation, and necrotic cell death

These conventional therapies present challenges such as treatment cost, infection risk, poor patient compliance, organ rejection, availability issues, and the need for immunosuppressant drugs and frequent dialysis [223,224,225]

It can affect diabetes, chemotherapy, and thyroid meds