IGF-1 activates the PI3K/Akt/mTOR pathway in muscle cells, stimulating protein synthesis, nitrogen retention, and hypertrophy
There is one Phase I trial registered as NCT02637284 in 2015, intended to enrol forty-two participants, which was subsequently cancelled with no published results [7]
Other, much less common side effects of sermorelin may include: difficulty swallowing dizziness flushing (redness in the face or neck) headache nausea rash sleepiness taste changes trouble sitting still Drug interactions Sermorelin may interact with other medications, including: thyroid medications (levothyroxine) cyclooxygenase inhibitors (aspirin) glucocorticoids (prednisone) insulin muscarinic antagonists (atropine) somatostatin-containing drugs or drugs that affect somatostatin (levodopa) Before starting sermorelin treatment, make sure to let your doctor know about any medications and supplements you take (including vitamins)
Protein intake matters because GLP-1 medications suppress appetite so effectively that many people accidentally eat 40% or more less protein, which speeds up muscle loss
doi: 10.1016/j.cell.2017.02.031
