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Detoxification of reactive oxygen species is an essential task within the brain as excessive free radicals can damage nerve cells in the brain which may lead to poor energy production, fatigue, and memory issues

Verma et al., 2021)

Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis

The main interoceptive cortical regions are the insula, the cingulate gyrus, the somatosensory cortex and some zones of the frontal cortex (250, 251)

But the field shifted toward understanding ghrelin biology, and pharmaceutical investment in GH secretagogues for anti-aging applications declined as regulatory scrutiny of growth hormone-related products increased through the 2000s and 2010s