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Why it's relevant to psoriasis: Directly inhibits NF-B activation (central to psoriatic inflammation) Reduces pro-inflammatory cytokine production Used in inflammatory bowel disease research (similar immune dysregulation) No melanin-related effects unlike full alpha-MSH Research context: KPV has shown efficacy in reducing gut inflammation in colitis models

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Trained practitioners provide the appropriate amount, provide clean facilities, and observe for any untoward side effects