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Retatrutide's labeling in phase 2 excluded these patients explicitly [2]

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Beyond 12 months Clinical trials for both Mounjaro and Wegovy show continued weight loss beyond 12 months at therapeutic doses, with average total weight loss of 20 to 22% for tirzepatide 15mg and 14 to 15% for semaglutide 2.4mg at the end of 72-week and 68-week trials respectively